CiRA Member
PI: Akitsu Hotta
- Place of birth: Nagoya, Japan
- Favorite food: Miso-katsu (deep-fried pork cutlet served with sweet miso source [local food in Nagoya])
- Interest: Playing the keyboard, Downhill skiing, Watching movies (from classic to Hollywood, but except for horror)
- Special skills: DIY (including this website!)
| March 2001 |
B.Sc., Department of Engineering, Nagoya University. (Nagoya, Japan)
Construction of Protein secondary structure library using C-language on UNIX system. (Go to Yamane Lab) |
| March 2006 |
M.Sc. and Ph.D. (Bioengineering), Nagoya University. (Nagoya, Japan)
Generation of transgenic chicken for producing pharmaceutical protein. (Go to Iijima Lab) |
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April 2006 ~ February 2010 |
Postdoctoral Research Fellow Developmental & Stem Cell Biology, Hospital for Sick Children. (Toronto, Canada) Development of gene therapy vectors for hemoglobinopathy and neurodevelopmental disorder Rett Syndrome, and pluripotent stem cell-specific vector for marking ES/iPS cells. (Go to James Ellis lab) |
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June 2008 ~ February 2010 |
Research Fellow, Ontario Human iPS Cell Facility. (Toronto, Canada)
Optimization of iPS cell induction and characterization of iPS cell lines. (Go to the Facility website) |
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October 2010 ~ March 2014 |
PRESTO (Precursory Research for Embryonic Science and Technology) Researcher, Japan Science and Technology Agency (JST). "Understanding Life by iPS Cell Technology" field, Phase III (Go to the JST PRESTO website) |
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March 2010 ~ October 2016 |
Principal Investigator, Assistant Professor Department of Reprogramming Science, Center for iPS Cell Research & Application (CiRA), Kyoto University. (Kyoto, Japan) Assistant ProfessorYamanaka Group, Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University. (Kyoto, Japan) |
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April 2016 ~ Present |
Principal Investigator Hotta Project, T-CiRA Program (Go to the T-CiRA website) |
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October 2016 ~ April 2022 |
Principal Investigator, Junior Associate Professor Department of Life Science Frontiers, Center for iPS Cell Research & Application (CiRA), Kyoto University. (Kyoto, Japan) |
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May 2022 ~ Present |
Principal Investigator, Associate Professor Department of Clinical Application, Center for iPS Cell Research & Application (CiRA), Kyoto University. (Kyoto, Japan) |
| November 2009 |
Hospital for Sick Children (SickKids) Exceptional Trainee Award |
| April 2016 |
The Commendation for Science and Technology by the Minister of MEXT The Young Scientists’ Prize |
| May 2020 | Japanese Society for Regenerative Medicine Award (Basic Research) |
Assistant Prof.：Yusuke Kojima, Ph.D.
- Place of birth: Tokoname, Aichi, Japan
- Favorite food: Ramen noodles, meats, beer
- Interest: Tennis, Workout
- Skill: I can (often) explain difficult things in a way that's easy to understand for people.
- Comment: It has been my dream to be a leading scientist since I was a child. I would like to contribute to science which gradually progresses in between dream and reality.
- Motto: Great talents mature late.
| March 2010 | B.Sc., Department of Engineering, Nagoya University. (Nagoya, Japan) |
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April 2010 ~March 2015 | M.S. and Ph.D.: Department of Chemistry and Biotechnology, Graduate School of Engineering, Nagoya University (Dr. Iijima’s Lab) |
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March 2015 ~ March 2020 | Research Fellow: Department of Oncology, Mayo Clinic (Dr. Machida’s Lab) |
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March 2020 ~ June 2020 | Research Associate: Department of Oncology, Mayo Clinic (Dr. Machida’s Lab) |
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July 2020 ~ March 2021 | Postdoctoral Researcher: Department of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto University |
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April 2021 ~ present | Assistant Professor: Department of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto University |
| August 2013 |
Presentation Award Central Japan Branch of the Society for Biotechnology, Japan |
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Huang J, Zhou Q, Gao M, Nowsheen S, Zhao F, Kim W, Zhu Q, , Yin P, Zhang Y, Guo G, Tu X, Deng M, Luo K, Qin B, Machida Y, Lou Z. Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging. Molecular Cell, 2020 Jul 1;S1097-2765(20)30429-9. doi: 10.1016/j.molcel.2020.06.027. [PubMed link] [Journal link] |
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, Machida Y, Palani S, Caulfield TR, Radisky ES, Kaufmann SH, Machida YJ. FAM111A protects replication forks from protein obstacles via its trypsin-like domain. Nature Communications, 2020 Mar 12;11(1):1318. doi: 10.1038/s41467-020-15170-7. [PubMed link] [Journal link] *Selected as the Nature Communications Editors’ Highlights by Anne Mirabella |
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Maskey RS, Flatten KS, Sieben CJ, Peterson KL, Baker DJ, Nam HJ, Kim MS, Smyrk TC, , Machida Y, Santiago A, van Deursen JM, Kaufmann SH, Machida YJ. Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging. Nucleic Acids Research, 2017 May 5;45(8):4564-4576. doi: 10.1093/nar/gkx107. [PubMed link] [Journal link] |
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, Mizutani A, Okuzaki Y, Nishijima K, Kaneoka H, Sasamoto T, Miyake K, Iijima S. Analyses of chicken sialyltransferases related to N-glycosylation. Journal of Bioscience and Bioengineering, 2015 Jun;119(6):623-8. doi: 10.1016/j.jbiosc.2014.11.009. Epub 2014 Dec 8. [PubMed link] [Journal link] |
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, Wakita J, Inayoshi Y, Suzuki R, Yamada Y, Kaneoka H, Nishijima K, Iijima S. Galactosylation of human erythropoietin produced by chimeric chickens expressing galactosyltransferase. Journal of Bioscience and Bioengineering, 2014 Jun;117(6):676-9. doi: 10.1016/j.jbiosc.2013.11.010. Epub 2013 Dec 17. [PubMed link] [Journal link] |
Postdoc：Matthew Beucler, Ph.D.
- Place of birth: Ohio, America
- Favorite food: Sushi and pizza
- Interest: Video games, cats, and martial arts
- Motto: Be humble and kind.
| December 2014 | B.S., Department of Microbiology, The Ohio State University |
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January 2015 ~ June 2016 | Research assistant: Department of Microbiology, The Ohio State University |
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July 2016 ~ May 2022 | Ph.D, Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati |
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July 2022 ~ present | Postdoctoral Researcher: Department of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto University |
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, Miller WE. Rescue of Pentamer-Null Strains of Human Cytomegalovirus in Epithelial Cells by Use of Histone Deacetylase Inhibitors Reveals an Additional Postentry Function for the Pentamer Complex. Journal of Virology, 2022 Apr 27;96(8):e0003122. doi: 10.1128/jvi.00031-22. [PubMed link] [Journal link] |
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Morrison KM, , Campbell EO, White MA, Boody RE, Wilson KC, Miller WE. Development of a Primary Human Cell Model for the Study of Human Cytomegalovirus Replication and Spread within Salivary Epithelium. Journal of Virology, 2019 Jan 17;93(3):e01608-18. doi: 10.1128/JVI.01608-18. [PubMed link] [Journal link] |
Postdoc： Hooi Ting Hu Ph.D.
- Place of birth: Malaysia
- Favorite food: Curry, tomyam, fried chicken, hot pot
- Interest: Singing, instruments (keyboard, ukulele), travel, photography
- Special skills: I can make beautiful illustration using Adobe Illustrator
- Motto: Keep calm and carry on
| Aug 2017 | B. Sc., Department of Biomedical Science, University Putra Malaysia |
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Apr 2018 ~ Mar 2024 |
M.S. and Ph.D., Division of Biological Science, Nara Institute of Science and Technology (Suetsugu Lab) |
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June 2024 ~ present | Postdoctoral Researcher: Department of Clinical Application, Center for iPS Cell Research and Application (CiRA), Kyoto University |
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Nishimura, T.*, Oyama, T.*, *, Fujioka, T.*, Hanawa-Suetsugu, K., Ikeda, K., Yamada, S., Kawana, H., Saigusa, D., Ikeda, H., Kurata, R., Oono-Yakura, K., Kitamata, M., Kida, K., Hikita, T., Mizutani, K., Yasuhara, K., Mimori-Kiyosue, Y., Oneyama, C., Kurimoto, K., Hosokawa, Y., Aoki,J.,Takai,Y.,Arita, M., Suetsugu, S. (*: equal contribution) Filopodium-derived vesicles produced by MIM enhance the migration of recipient cells. Developmental Cell, 56, 842-859 e848, Mar 2021. |
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# , Nishimura, T., and Suetsugu, S.# (# : Co-corresponding authors). Ultracentrifugal separation, characterization, and functional study of extracellular vesicles derived from serum-free cell culture. STAR Protocols, 2, 100625, Jun 20 |
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Mukherjee, A., Ron, J. E., , Nishimura, T., Hanawa-Suetsugu, K., Behkam, B., MimoriKiyosue, Y., Gov, N. S., Suetsugu, S., & Nain, A. S. Actin filaments couple the protrusive tips to the nucleus through the I-BAR domain protein IRSp53 during the migration of cells on 1D fibers. Advanced Science, 10(7), 2207368. Mar 2023. |
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, Suetsugu, S., & Nishimura, T. The extracellular vesicles. Plasma Membrane Shaping, 177-191, Jan 2023. |
Bioinformatician：Youichi Naoe, Ph.D.
- Place of birth: Saitama, Japan
- Favorite food: Fried rice
- Interest: Cooking
- Comment: My work at CiRA is mainly focusing on the analysis of NGS data. I hope my bioinformatics skills will contribute the applications of data analysis in the laboratory.
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Aug 2019 ~ Mar 2022 |
T-CiRA Program (Hotta Project) Contract Researcher CiRA, Kyoto University (Kyoto, Japan) |
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Apr 2022 ~ Present |
T-CiRA Program (Hotta Project) Researcher CiRA, Kyoto University (Kyoto, Japan) |
Technical Staff：Yukie Kumeta, Ph.D.
- Place of birth: Muroran, Hokkaido, Japan
- Favorite food: Sushi, Gyoza (Dumpling)
- Interest: Playing the violin
- Skill：I can guess most breeds of dogs.
- Motto：I always try to be grateful for everything.
- Comment: It’s been a while since the last time I worked for research. I would like to take a step forward to contribute to the development of science while having fun.
| March 2006 | B.Pharm., Faculty of Pharmaceutical Sciences, Kyoto University |
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Apr 2006 ~ March 2011 | M.Pharm. and Ph.D., Graduate school of Pharmaceutical Sciences, Kyoto University |
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Apr 2011 ~ March 2014 | Researcher: Division of Pharmacognosy, phytochemistry and narcotics, National Institute of Health Sciences |
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Apr 2014 ~ March 2016 | Researcher: Graduate school of Pharmaceutical Sciences, Kyoto University |
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Nov 2023 ~ Present | Assistant research staff, Department of Clinical Application, CiRA, Kyoto University |
Technical Staff：Chika Kuwabara
- Place of birth: Wakayama, Japan
- Favorite food: Chocolate（bitter）
- Interest: Drive, yoga
- Skill：Relaxing at home
- Habit："No problem"
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Mar 2021 ~ Present | Technical Staff: Department of Clinical Application, CiRA, Kyoto University |
Technical Staff：Yumi Tsubokura
- Place of birth: Kyoto, Japan
- Favorite food: Cheese, chestnuts, sweet potatoes, pumpkins
- Interest: Cooking, Mizuhiki accessories
- Skill：Massage, cooking medicinal dishes
- Comment: Although I am still learning English, I would like to work and communicate with everyone in both Japanese and English.
| March 2011 | M.Sc., Human Health Sciences, Graduate School of Medicine, Kyoto University |
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Nov 2013 ~ Nov 2016 | Technician, School of Engineering, The University of Tokyo |
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Sep 2017 ~ April 2020 | Technical staff, Rheumatology and Clinical lmmunology, Showa University |
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June 2020 ~ Dec 2021 | Technical staff, RegeNephro Inc. |
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Mar 2023 ~ Present | Technical Staff, Department of Clinical Application, CiRA, Kyoto University |
Ph.D. Student: Joseph Lee
- Place of birth: Canada
- Favorite food: Yakiniku, Chinese food
- Interest: Reading, PC game, finding good restaurant
- Speciality: Optimistic mind
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2014 ~ 2018 | B.Sc., University of Toronto (Canada, Toronto) Department of Cell and Systems Biology |
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Oct 2018 ~ Mar 2020 | Research Student, SickKids Hospital (Canada, Toronto) |
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Apr 2020 ~ Mar 2022 | M.Sc. Student, Graduate School of medicine, Kyoto University / Department of Clinical Application, Hotta lab, CiRA, Kyoto University |
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Apr 2022 ~ Present | Ph.D. Student, Graduate School of medicine, Kyoto University / Department of Clinical Application, Hotta lab, CiRA, Kyoto University |
Ph.D. Student：Uikyu_Bang
- Place of birth: Republic of Korea
- Favorite food: Shushi, Ramen
- Interest: Workout, Photography
- Skill: Sociability, Carefulness
- Motto: Always have the feeling of trying everywhere without giving up
| Mar 2019 | Department of Biology, Faculty of Science, Tohoku University |
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Apr 2021 ~ March 2023 | M.Sc. Student, Graduate School of medicine, Kyoto University / Department of Clinical Application, Hotta lab, CiRA, Kyoto University |
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Apr 2023 ~ Present | Ph.D. Student, Graduate School of medicine, Kyoto University / Department of Clinical Application, Hotta lab, CiRA, Kyoto University |
M.Sc. Student：Jason (Ka Ming) Choi
- Place of birth: Hong Kong
- Favorite food: Ramen, parfait, meat
- Interest: Reading novels, enjoying dessert
- Motto: Do not regret what you have done
| July 2020 | B.Sc. in Biochemistry, Chinese University of Hong Kong |
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Sep 2020 ~ March 2022 | Research Technician, Rohto Advanced Research Hong Kong |
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Apr 2023 ~ present | M.Sc. Student, Graduate School of medicine, Kyoto University / Department of Clinical Application, Hotta lab, CiRA, Kyoto University |
Research Student：Yuqin Feng
- Place of birth: China
- Favorite food: Garlic flavor, vegetables
- Interest: Photography, hiking, video game
- Special skills: Multitask
- Motto: Love all, serve all
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Sep 2018 ~ June 2023 | M.D., Zhejiang University |
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Aug 2023 ~ present | Research Student, Department of Clinical Application, Hotta lab, CiRA, Kyoto University |
Secretary: Miyuki Nakamura
- Place of birth: Toyama, Japan
- Favorite food: Thai food
- Interest: I recently started visiting temples.
- Skill: Not shy
- Motto: Tomorrow is another day
- Comment: I'll enjoy doing my job.
T-CiRA Member
Technician: Naoko Fujimoto
- Place of birth: Shizuoka, Japan
- Interest: Travel, Running
| Mar 2008 |
M.Sc., Nara Institute of Science and Technology (NAIST). (Nara, Japan)
Laboratory of Molecular and Cell Genetics, Bioscientific Research Course, Graduate School of Science and Technology |
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Apr 2008 ~ June 2010 |
Research Technician
Laboratory of Molecular and Cell Genetics, Graduate School of Science and Technology, Nara Institute of Science and Technology (NAIST). (Nara, Japan) |
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July 2010 ~ July 2014 |
Research Technician
Department of Reprogramming Science, Center for iPS Cell Research & Application (CiRA), Kyoto University. (Kyoto, Japan) |
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Aug 2014 ~ Mar 2015 |
Research Technician
Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo (Tokyo, Japan) |
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April 2015 ~ March 2016 |
Technical staff
Mikiko Sodeoka Research Group, Synthetic Organic Chemistry Laboratory, RIKEN (Saitama, Japan) |
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Apr 2016 ~ Present |
Technical Researcher
T-CiRA Hotta Project, CiRA Satellite Lab at Shonan Research Center (Shonan, Japan) |
Contract Researcher: Dongyang Li, Ph.D.
- Place of birth: China
- Favorite food: Dumplings, Sushi, Hot pot
- Interest: Travel, Sports, Yoga
- Motto: Stay hungry, stay foolish
- Comment: I would like to contribute to the development of science and the human healthcare.
| July 2014 | Shenyang Pharmaceutical University, Department of Pharmacy, |
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Oct 2014 ~ Sep 2019 | Master and Ph.D., Ochanomizu University, Graduate school of science, |
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Jan 2020 ~ Mar 2021 | Postdoctoral fellow, Tsukuba University, Department of Medicine |
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2021年4月 ~ 2022年3月 | Postdoctoral fellow, Institute of advanced industrial and sciences and technology |
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Apr 2023 ~ Mar 2024 | Specially appointed assistant professor, Nagoya University, Graduate School of Medicine |
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July 2024 ~ present | Contract Researcher, T-CiRA Hotta Project, CiRA Satellite Lab at Shonan Research Center (Shonan, Japan) |
| Dietary β-conglycinin prevents acute ethanol-induced fatty liver in mice. Ikaga R, Li D, Yamazaki T. Biochem Biophys Res Commun. 2017 Nov 4;493(1):542-547. |
| Soya protein β-conglycinin ameliorates fatty liver and obesity in diet-induced obese mice through the down-regulation of PPARγ. Li D, Ikaga R, Yamazaki T. Br J Nutr. 2018 Jun;119(11):1220-1232. |
| Effective Food Ingredients for Fatty Liver: Soy Protein β-Conglycinin and Fish Oil. Yamazaki T, Li D, Ikaga R. Int J Mol Sci. 2018 Dec 18;19(12):4107. |
| A novel method for measuring diet-induced thermogenesis in mice. Yamazaki T, Ikaga R, Li D, Nakae S, Tanaka S. MethodsX. 2019 Sep 10;6:1950-1956. |
| Fish Oil Increases Diet-Induced Thermogenesis in Mice. Yamazaki T, Li D, Ikaga R. Marine Drugs. 2021 May 17;19(5):278. |
Photo Gallery
Dec 2023: Lab photo
Apr 2022: Lab photo
Sep 2018: Lab photo
Apr 2017: Lab photo
Apr 2016: Sakura party
Apr 2015: Sakura party
Apr 2014: Lab photo
Apr 2011: Lab photo
Kiyomizu Temple
Ceremonial bonfire of Gozan
Internship Student
| Student | Affiliation | Enrollment period | Program |
| Kensho Gendzwill | University of Washington | June 6 - July 31, 2023 | Amgen Scholars |
| Maho Tamatani | Sophia University | Aug 19 - Sep 25, 2019 | CiRA Internship Program |
| Nanaoko Shirai | Princeton University | Aug 8 - Sep 7, 2018 | CiRA Internship Program |
| Xiou Wang | Brandeis University | Jun 11 - Aug 6, 2018 | Brandeis University, WOW Fellowship |
| Yasuko Abe | School of Science, University of Tokyo | Aug 21 - Sep 29, 2017 | CiRA Internship Program |
| Lucy Yang | MIT | Jun 14 - Aug 30, 2017 | MISTI Internship Program |
| Linxin Gu | Sichuan University | Jul 3 - Aug 10, 2017 | CiRA Internship Program |
| Julia Kudryashev | MIT | Jun 6 - Aug 12, 2016 | CiRA Internship Program, MISTI Internship Program |
| Matthew Waller | Duke University | May 19 - Jul 14, 2016 | Robertson Scholars Leadership Program |
| Tomoharu Suzuki | Faculty of Medicine, Kyoto Univ. (3rd grade) | Aug 31 - Oct 19, 2015 | My Course Program |
Alumni
| Name | Enrollment period | Next Position |
| Kei Watanabe | April 2018 ~ March 2022 | Kowa Company Ltd. |
| Eman Taha | Nov 2020 ~ Jan 2022 | Ain Shams University |
| Noriko Sasakawa | Aug 2010 ~ May 2020 | Tohoku Medical and Pharmaceutical University |
| Miyuki Ono | Apr 2018 ~ Apr 2020 | Bio-venture |
| Kumiko A. Iwabuchi | May 2017 ~ Apr 2020 | Tokyo University of Science |
| Yuya Okuzaki | Feb 2018 ~ Mar 2020 | Avian Bioscience Research Center, Nagoya University |
| Akihiro Kagita | Apr 2017 ~ Mar 2020 | Faculty of Medicine, Yamaguchi University |
| Huaigeng Xu | Apr 2015 ~ Feb 2020 | UCSF Robert Blelloch lab |
| Mandy Lung | Jun 2015 ~ Dec 2019 | CiRA, Kyoto University |
| Peter Gee | Dec 2014 ~ Mar 2019 | MaxCyte, Inc. |
| Takahiro Iguchi | Nov 2017 ~ Dec 2018 | The University of Tokyo |
| Masakata Ifuku | May 2016 - Apr 2018 | Takeda Pharma Inc. |
| Masami Tanaka | May 2016 - Aug 2017 | DeNA Life Science |
| Kentaro Ishida | Nov 2014 - Jul 2017 | Myoridge Co. Ltd. |
| Ryota Saeki | Apr 2014 - Mar 2016 | Sumitomo Dainippon Pharma |
| Hongmei Li (李 紅梅) | Apr 2012 - Jun 2015 | Boston Children’s Hospital / Harvard Medical School |
| Saya Shirai | Feb 2011 - Mar 2014 | Research Institute for Sustainable, Kyoto Univ. |
| Takao Nakano | Apr 2011 - Mar 2014 | IT company |