iPS cell × Genome editing =

Biotechnology to make the impossible possible

For many intractable diseases such as muscular dystrophy caused by a genetic mutation, there is no effective treatment even with modern medical science. Human genome sequences can be decoded by deep sequencers, but methods to rewrite and repair are still under development.

To make it possible to cure genetic abnormalities, which is the root cause of many intractable diseases, we are developing and studying gene therapy methods for various diseases using state-of-the-art genetic engineering and advanced stem cell engineering.

Hotta lab works to realize new "iPS cell gene therapy" by using patient iPS cells, gene delivery vectors, bioinformatics, and genome/epigenome editing technologies centering on the CRISPR-Cas system.